COMMON MICROORGANISMS OF MEDICAL IMPORTANCE
common microorganisms of medical importance
and the disease they cause
Definitions of Terms
Prokaryote-microorganisms a with simple cell structure
Eukaryote-
microorganisms a with
complex cell structure.
ACTIVITY:
Define the following terms:
- Prokaryote
- Eukaryote
Explain prokaryote and eukaryote
PROKARYOTES
- microorganisms a with simple cell structure
- They
include;bacteria,rickettsiae,Mycoplasma,chlamydiae
- Genetic material is not well organised
- Have single piece on DNA in cytoplasm
- Cell has simple enzyme system
- They lack mitochondria
- Multiply by binary fission
EUKARYOTE
- microorganisms a with complex cell structure.
·
Includes protozoa
and fungi
·
Genetic material
is differentiated in to chromosomes(DNA and RNA)
·
Cells is able to
make its own energy
·
Posses complex
enzyme system, mitochondria and other organelles.
·
Multiply by
mitosis
common groups of micro organisms of
medical importance and the diseases they cause
·
Bacteria-causes bacteraemia and septicaemia
·
Mycoplasma-Eye infection
·
Ricketssiae-Typhus fever
·
Protozoa-parasitic infection
·
fungi -Dermatophytis
·
viruses-viral infection
Explain the characteristics of each bacteria
above
BACTERIA
- Are unicellular
- Measures 0.1-10um long
- Have both DNA and RNA
- Multiplyby binary fission
- Classified according to staining
reactions,cultural characteristics,Biochemical reactions,serologically.
- Sensitive to antibiotics
- Can be seen in light microscope
·
Sensitive to some
antibiotics
RICKETSSIAE-
- They multiply replication in living cells only
- Has both DNA and RNA
- Can be seen in light microscope
·
Sensitive to some
antibiotics
CHLAMYDIA
- Gram –ve
- Measures 250-500 nm
- Replicate in living cells
- Has both DNA and RNA
MYCOPLASMA
- Lack rigid cell wall
- Measures 0.1-2.0um in diameter
- Can be grown in ordinary media
- The smallest and simplest organism
FUNGI
- Are non photosynthetic
- Cells are relatively rigid
- Can be saprophytic or parasitic
- Are eukaryotic cells
- Multiply by budding
- Are dimorphic
VIRUSES
- Have either DNA or RNA
- Multiply by replication
- Are intracellular
- Measures 20-300nm(0.02-0.3um)
- The infective subatance is known as virion
- Can be seen by electron microscope only
- Can grow only within living cell
- Have cell wall known as capsid
Explain the basic features of bacteria cell (drawing)
BACTERIA CELL STRUCTURE
Bacterial cell consists of the
following parts
- NUCLEUS-A structure in the cell which controls the activity and
functions of the cell.It consists of DNA and RNA
- CYTOPLASM-A fluid substance in a bacterial cell.
It suspends the cell
organelles.
- CYTOPLASMIC MEMBRANES-Encloses the
cytoplam.Its involved in selective permeability and transprt of
nutrients.The membrane is permeable ie allows materials to pass in and out
of the cell.e.g nutrients.
- MESOSOMES-Are specialized
invaginations on the cell memebrane involved in cell division.
- FLAGELLA-Are thread like
structures protein in nature used by bacteria for locomation.
- PILLI(FIMBRIAE)-Are protein like
structures finer in nature used by the bactreria for attachment to the
host and in transfer of genetic materials from donor to recipient.Are
shorter than flagella
- CAPSULE-A thick polysaccharide
substance produced by the bacteria.It Surrounds the cell wall af a
bacteria.It protects the bacteria from adverse conditions.it contributes
to the invasiveness of a bacteria.
- CELL WALL-This is the structure
that encloses the whole bacteria cell.It contains high concentrations of
inorganic ions.The cell wall is strong to prevent fluid from being drawn
into it.The cell wall gives the basis of classifying bacteria into Gram
positive and Gram negative.
DRAWING
List the morphology of bacteria
a)Cocci-diplococci-(occurs in pairs;e.g Neisseria gonorrhoeae, Neisseriae
mennigitidis)
-Staphylococci-(occurs
in groups.e.g Staphylococci aureus)
-Streptococci-(occurs
in chains.Streptococcus pneumoniae)
-Gaffkya-(
occurs in 4 packets)
-Sarcina-(occurs
in 8 Packets)
b)Rods(Bacilli)-E.g Escherichia coli,bacillus anthracis
c)Comma shaped(vibrio’s)-are curved rods.E.g Vibrio cholera
d)Spirochaetes
e)Spirilla
Describe the physiology of bacteria cell wall
The wall of bacterial has a
strong wall composed of murein and mucopeptide(peptidoglycan).
Differences in bacterial cell
wall leads to differences in staining of
bacteria.The cell wall is rigid, semi-permeable and maintains the shape of a
bacteria.
Bacteria are classified into
two major groups
GROUPS OF BACTERIA
- Gram positive
- Gram negative
GRAM POSITIVE BACTERIA
• They retain the purple color
of crystal violet stain after decolourization with acetone
.
GRAM POSITIVE BACTERIA CELL WALL
• The cell wall structure
consists of
·
peptidoglycan layer(thick layer)
·
Techoic acid
·
Robitol phosphate
·
Glycerol phosphate
• Peptidoglycan layer consists
of
Ø N-Acetyl glucosamine and N-Acetyl
muramic Acid
Ø Tetra peptide chains attached
to N-Acetyl muramic acid
Ø Peptide cross-bridge
Techoic acid contains major
surface antigens of Gram positive species
GRAM NEGATIVE BACTEIA CELL WALL
• They take up the red color
of the counter stain(neutral
red/safranin) after decolourization with acetone
• The wall consists of :-
Ø Lipopolysaccharide layer
Ø Outer membrane(thin layer)
Ø Cytoplasmic membrane
Importance of microorganisms
·
Manufacture of antibiotics e.g
penicillin
·
Used as food eg. Mushrooms
·
Manufacture of biological weapon
·
Bio-degradation e.g plastic decomposition
:key points
Prokaryote-microorganisms a with simple cell structure
Eukaryote-
microorganisms a with
complex cell structure.
BACTERIA
- Are unicellular
- Measures 0.1-10um long
- Have both DNA and RNA
- Multiplyby binary fission
- Classified according to staining
reactions,cultural characteristics,Biochemical reactions,serologically.
- Sensitive to antibiotics
- Can be seen in light microscope
·
Sensitive to some
antibiotics
: List
the morphology of bacteria
a)Cocci-diplococci-(occurs in pairs;e.g Neisseria gonorrhoeae, Neisseriae
mennigitidis)
-Staphylococci-(occurs
in groups.e.g Staphylococci aureus)
-Streptococci-(occurs
in chains.Streptococcus pneumoniae)
-Gaffkya-(
occurs in 4 packets)
-Sarcina-(occurs
in 8 Packets)
b)Rods(Bacilli)-E.g Escherichia coli,bacillus anthracis
c)Comma shaped(vibrio’s)-are curved rods.E.g Vibrio cholera
d)Spirochaetes
e)Spirilla
Evaluation
- Define
- Prokaryote
- Eukaryote
- List 5 characteristics of bacteria
- Mention 5 parts of a bacteria cell
- Mention the morphology bacteria
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